Taking more than the recommended dose increases the risk of liver damage
Researchers analyzing body composition data have noted not only greater overall weight reduction but also a favorable ratio of fat loss to lean mass preservation, consistent with the hypothesized energy-expenditure component
Moreover, the degree and trajectory of weight loss may have differed substantially between semaglutide users and controls, particularly if weight loss in the control group was achieved through lifestyle-related approaches rather than pharmacologic treatment, but these differences could not be measured within TriNetX
However, when Ozempic is combined with insulin or sulfonylureas (medications that independently lower blood sugar), the hypoglycemia risk increases to approximately 6-10%
Tietge UJF, et al
The situation underscores just how dominant those weight loss drugs have become in American society, not only in terms of their popularity, but also as a matter of urgent public policy, as the rapidly escalating outlays have blown holes in insurance coverage and triggered a backlash thats resulted in a pulling back of access
