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The corrin ring structure, which is the molecular backbone of vitamin B12, appears to alter the pharmacokinetic profile in a way that reduces central nervous system exposure to the emetogenic (nausea-causing) effects while preserving the metabolic benefits

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Clinical literature references loading phases, maintenance phases, and cycle durations that vary by provider and patient profile

14 weeks Reduced tingling & burning for some patients 23 months Better sensation, improved balance, reduced pain 6 months+ Nerve repair and long-term function improvement Severe or long-standing neuropathy may require ongoing treatment