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This fatty shell acts as a protective shield for the glutathione tucked inside

RNA data-analysis Read counts for genes were obtained by aligning the reads to the reference genome (Genome Reference Consortium Human Build 38, GRCh38.p7) using RSEM 61 (v.1.2.28) with the paired-end and Bowtie2 62 (v.2.2.6) option

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Liver/Kidney/CYP450: High-dose systemic copper chelate therapy requires strict monitoring of ceruloplasmin and unbound serum copper to prevent heavy metal toxicity or Wilson-like hepatic accumulation

Wu YH, Chen N, Xuan, et al

523 Analysis of gene expression in cortical astrocytes from old mice identified an increase in genes linked to an immune response with a decrease in expression of GFAP and genes related to neuroprotection and neuronal support, 524 and the prominent up-regulation of genes contributing to synapse elimination in astrocytes from aged hippocampus and cerebellum