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Mechanism and Effects of Pulsatile GABA Secretion from Cytosolic Pools in the Human Beta Cell. Nature Metabolism, vol

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The extensive SUSTAIN and STEP clinical trial programmes, which evaluated semaglutide's safety and efficacy, have not shown a signal for increased incidence of gastrointestinal bleeding compared to placebo or active comparators, as documented in the European Medicines Agency's European Public Assessment Report (EPAR)

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After the 26-week treatment period, the mean percentage of weight reduction from baseline was greater with all doses of cagrilintide (0.34.5 mg, 6.0%10.8%) versus placebo (3.0%)