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Mulvihill EE, Varin EM, Gladanac B et al (2017) Cellular sites and mechanisms linking reduction of dipeptidyl peptidase-4 activity to control of incretin hormone action and glucose homeostasis
The deeper reality is that GLP-1 medications reshape your microbiome, and the state of your microbiome determines how you experience those digestive changes
GI side effects like diarrhea deplete magnesium rapidly
Id also raise the question of whether the incretins and other GLP-1 agonists will ever be free of adverse GI symptoms, as it seems intrinsic to the drugs mechanism
The safety of metformin with tirzepatide is well-established for stable use, but the interaction dynamics during medication transitions have not been specifically studied
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