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This review focuses on how GLP-1RAs impact lipid-related outcomes

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The remaining 76 articles underwent a full-text screening process, during which 38 articles were excluded for the following reasons: 4 wrong focus, 13 cells of animal origin and 21 due to an unfitting cell type

ClinicalTrials.gov NCT04881760) reported the largest mean body-weight reductions observed to date in incretin-class trials at peak dose, while open-label Phase 3 work in the TRIUMPH program is ongoing

Tirzepatide, without glucagon agonism, does not carry that specific signal

Tirzepatide works with two signals, making it a dual agonist that targets both GLP-1 and GIP receptors