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Clinical trial data revealed that 1.5% of patients on the 0.5mg dose developed gallstones compared to 0% in the placebo group, with 90% of these cases being serious enough to require cholecystectomy (surgical gallbladder removal) yet this information wasnt prominently disclosed to prescribers or patients for over four years

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PMID: 38927473

3q), suggesting that these animals are sensitised to GLP-1R agonism, supporting our previous observation that sensitivity to GLP-1R agonism is enhanced in mice lacking Gipr in the hypothalamus 7

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