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Overuse of opioids might lead to serious consequences, such as respiratory depression, addiction, and even death (96, 97)

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New insights in the mechanisms of weightloss maintenance: summary from a Pennington symposium

In a phase 1, 12-week study with multiple ascending doses, placebo-adjusted mean decreases in HbA1c of up to 1.56% and body weight decreases of up to 8.96 kg were observed [67]