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Cottrill A, Cubanski J, Neuman T, Smith K

Recent research indicates that neuronal ATP and adenosine interact with their respective receptors-P2X and P2Y for ATP, and adenosine A 2A receptors (A 2A R) for adenosine-leading to pericyte contraction, which reduces CBF, or membrane hyperpolarization, which increases CBF [26, 87,88,89]

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The result is pain that persists despite careful rest

CGRP released from cutaneous trigeminal nerve fibers and acts on surrounding Schwann cells, perpetuating cutaneous allodynia through a cyclic AMP-dependent mechanism that generates NO in endosomes (31)

SS-31 vs MOTS-C The Mitochondrial Peptide Comparison Both SS-31 and MOTS-C are mitochondria-related peptides, but they work through fundamentally different mechanisms