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FIGURE 6 3.7 L-Carnosine inhibits LPS-induced inflammatory responses and M1 polarization in mouse BMDMs To investigate the anti-inflammatory properties of L-carnosine in LPS-activated macrophages, primary mouse bone marrow-derived macrophages (BMDMs) were pretreated with increasing concentrations of L-carnosine (5 and 10 mM) for 1 h prior to stimulation with LPS (100 ng/mL) for 24 h

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In many cases, peptides were evaluated in isolation, at supraphysiologic doses, and without consideration of compensatory physiological mechanisms

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[Abstract]2021 Aug 21;2021:5526053