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People with a severe deficiency or absorption problems can feel the effect wear off sooner

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PubMed: 18283677 Pharmacokinetics and Bioavailability of AOD 9604 in Healthy Subjects human pilot Wallace JD, Cuneo RC, Lundqvist G, et al

The peptide, derived from the C-terminal fragment of human growth hormone (amino acids 176-191), targets adipose tissue specifically without the broader metabolic effects associated with full growth hormone therapy

If your skin changes quickly after starting supplements, it may be linked