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Unlike most peptides, which bind to a specific GPCR or tyrosine kinase, AOD-9604 acts via several indirect pathways with a predominance of effects on adipocytes (fat cells)

Mechanism of Interest MC1R activation: Stimulates increased eumelanin production in skin cells, leading to enhanced pigmentation and UV protection

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The findings with liraglutide treatment reviewed here need verification in larger populations in dedicated placebo-controlled RCTs

10.1126/scitranslmed.3007154 Sci Transl Med

Domperidone use is restricted due to cardiac risks (QT prolongation) and should only be considered when benefits clearly outweigh risks, avoiding use in patients with cardiac conditions or those taking other medications that affect heart rhythm