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Dipeptidyl peptidase-4 inhibitors: anti-diabetic drugs with potential effects on cancer

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The drugs popularity has been aided by an aggressive marketing campaign by Novo Nordisk, which spent $11m on meals and travel for physicians in 2022 alone, as well as unofficial promotion by social media influencers, celebrities and media outlets worldwide

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Animal data on LR3 infusion in pigs showed continued suppression of plasma growth hormone (~23% decrease) and IGFBP-3 across the 4-day infusion window (Tomas et al., 1997) by days 8-10 of a 10-day human community protocol, this kind of HPG-axis suppression would be expected to be active

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