Drugs where the same dose may result in significant individual differences in blood concentration, leading to substantial pharmacokinetic variability
Enzyme function is also compromised by copper deficiency, including that of copper-zinc SOD (Cu-Zn SOD), resulting in a weakened antioxidant defence system and increased vulnerability to oxidative stress, contributing to the development of atherosclerosis (103)
The complexes are as follows: I (NADHubiquinone reductase), II (succinateubiquinone reductase), III (ubiquinolcytochrome c reductase), IV (cytochrome oxidase), and V (ATP synthase complex F o F 1 ) [20]
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Psychoneuroendocrinology (2012) 37(11):188595