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An increased number of karyopyknotic cells was found in all four regions: cerebral and cerebellar cortex, hippocampus cortex, and hypothalamus/thalamus in control rats (Figure 8 and Figure 9)

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In the context of solid cancer, Darinaparsin was found to have preferential cytotoxic and radiosensitizing effects as compared with normal cells both in vitro and in a clinically relevant model (Tian et al., 2012, 2013)