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Phase 2 data (Jastreboff et al., NEJM 2023) showed mean pulse rate increases of approximately 3 to 5 beats per minute at higher doses, consistent with known GLP-1 receptor agonist pharmacology

Conversely, patients taking oral semaglutide 25 mg once daily may be transitioned to injectable semaglutide, with injectable therapy initiated the day after discontinuation of oral treatment, typically at a dosage of 2.4 mg once weekly

I mean, I guess what I'm getting into here is that whereas today we keep seeing the effects, whether it's the liver, the kidney, the heart, obesity, and people with diabetes

Neurobiol Aging 28: 13741380

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