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This marked elevation in LVEDP suggests central congestion, irrespective of no change in afterload (systemic pressure), and is a hallmark of heart failure 20

Deng et al., 2018

doi:10.2164/jandrol.106.000646

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A majority of studies have shown that Pro-Hyp and Hyp-Gly, which are resistant to peptidases in the human plasma, are the most (about 50%) and second most abundant food-derived 4-hydroxyproline-containing peptides in the plasma of healthy adult humans, rats and mice after consuming collagen hydrolysates (Osawa et al