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Since DC maturation and function are regulated by pathways such as JAK and MAPK (201), and CUL5 is known to modulate these key signaling cascades (116, 117, 125, 126), theoretically, modulating CUL5 could alter the immunostimulatory capacity of DCs within the tumor microenvironment

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When applied around a herniated disc, TB-500 appears to help seal tears in the outer annulus, preventing further disc material from leaking out

Its not a direct switch, and starting doses may need to be adjusted to avoid adverse effects