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Adverse events (AEs) were reported for 77.8% of survodutide-treated participants (mainly gastrointestinal), 52.5% receiving placebo and 52.0% receiving semaglutide

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The reduction in albuminuria and total eGFR slopes observed in the post hoc analysis of the SURPASS-4 trial with tirzepatide[14] and the remarkable risk reductions in composite kidney endpoints (eGFR decline 40%, renal death, kidney failure, or new-onset macroalbuminuria) in T2D patients with high baseline CVD risk compared to insulin glargine can be taken as a surrogate marker of this trend

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