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Venoji R, Amirtharaj GJ, Kini A, Vanaparthi S, Venkatraman A, Ramachandran A

This knowledge can help us find ways to intervene

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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

Interestingly, however, common responses to GLP1/E were observed in both PCOS models, with upregulation of hypothalamic pathways involved in autophagy and vesicle-mediated transport, and downregulation of pathways primarily related to the immune system