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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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Determine concentration: - For 1 mg vial + 2 mL bacteriostatic water = 500 mcg/mL - Each 0.1 mL = 50 mcg - For 20 mcg dose: draw 0.04 mL - For 40 mcg dose: draw 0.08 mL 2

This apparent paradox has driven researchers to investigate the deeper mechanisms at work