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Tolerance and dose adjustment over time Some people report decreasing effectiveness at a given dose after 6-12 months

Not a rough estimate

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DeFronzo RA

Newer research involving over 70,000 participants across 39 clinical trials paints a nuanced picture, one where certain types of clot risk may increase while overall cardiovascular outcomes actually improve

When to take oral semaglutide The best time to take oral semaglutide Rybelsus or the Wegovy pill is first thing in the morning , at least 30 minutes before any food, drinks, or other medications