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A: According to FDA prescribing information and clinical trial data, the most common side effects are gastrointestinal: Nausea : 20-44% of users (most common) Diarrhea : ~30% of users Constipation : 24-30% of users Vomiting : 9-24% of users Abdominal pain : 10-20% of users Side effects are typically most intense during first 1-2 weeks at a new dose level and improve significantly by weeks 3-4 at steady dosing