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Therefore, they cannot define long-term safety, cancer risk, reproductive effects, cardiovascular risk, or a general therapeutic role

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(iii) A 1955 report that patients with ischemic heart disease had improvement in angina and other cardiovascular symptoms while undergoing EDTA chelation therapy for lead poisoning sparked long, ongoing interest in the prevention and treatment of cardiovascular disease [108]

Buchner A, Merrell P, Hanson L, Leider A

3 This high prevalence has contributed to extensive morbidity and mortality, making this chronic condition the eighth leading cause of death in 2022