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Kidney Stones and Hydration Topiramate can increase the risk of developing kidney stones

Preclinical studies have explored possible mechanisms including improved endothelial function, reduced inflammation, and potential anti-atherosclerotic properties, though these effects require further investigation in humans before definitive conclusions can be drawn

Patients should be counseled to maintain adequate hydration and seek medical attention if they cannot tolerate oral fluids for 24 hours or experience signs of dehydration

They may also arrange blood tests to investigate treatable causes of fatigue, such as iron deficiency or thyroid dysfunction, which are common in the postnatal period and have evidence-based treatments compatible with breastfeeding

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Common side effects include nausea, vomiting, and injection site reactions