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In clinical trials on insulin resistance and type 2 diabetes, phenylbutyrate could significantly improve peripheral insulin sensitivity (Rd:13.2 1.8 vs
N Eng J Med (2018) 378:e34
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It also plays a role in maintaining nerve cells and constructing DNA
It improved GSH/GSSG ratios and reduced inflammatory cytokines (IL-6, TNF-alpha), which may support overall metabolic health
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