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What UAB Researchers Are Discovering The UAB article highlights that GLP-1 drugs dont just act in the gut they also have major effects in the brain

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The role of the autonomic nervous system in regulating energy balance and therapeutic implications Innervation of vagus nerve and energy homeostasis The autonomic nervous system (ANS) plays a pivotal role in maintaining energy balance by regulating both food intake and energy expenditure

Some worked well, some were too abrasive, and some didn't do much at all