Cardiovascular safety has been specifically evaluated through thorough QT studies, which demonstrated no clinically relevant QTc prolongation, indicating no increased risk of ventricular arrhythmias
Our data are consistent with the notion that energy substrates and glutathione produced in the liver are shuttled systemically and to the kidney to meet the metabolic demands of kidney repair and maintenance of redox balance
The explanation is that GLP-1 likely affects heart rate indirectly, through autonomic nervous system modulation rather than direct cardiac effects
Nausea and gastrointestinal symptoms are the most frequently reported side effects, affecting up to 40% of patients initiating therapy
For example, an employer might allow Wegovy with a $150 monthly copay under pharmacy benefits if the employee has a documented BMI35, but disallow it if BMI =35), documented lifestyle program participation, specialist prescribing, etc
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