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J Clin Psychopharmacol 2012;32:797803

Of the lesser-known side effects mentioned in the study, I have occasionally had patients report fatigue, but its not something I see frequently

Moreover, differences in experimental designincluding dietary models (HFD versus MCD), dosage regimens, intervention duration, and animal strainmay partially explain the divergent outcomes observed across studies

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GLP-1s work by mimicking the action of your GLP-1 hormone, which is naturally produced in the body and helps to regulate blood sugar levels, reduce hunger and cravings, and increase energy expenditure

The STEP 5 trial (the longest semaglutide study to date, running over two years) found no new side effects emerging over time, and the drug was generally well tolerated in the long run