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These early results prompted larger, Phase 3 trials known as the SURPASS and SURMOUNT programs

10 Overall, studies have consistently demonstrated the cardiovascular and weight loss benefits of GLP-1RAs across a variety of high-risk patient groups

Fontana et al., 2019)

The therapeutic reach of GLP-1 RAs is currently undergoing an "Indication Land Grab." As clinical data accumulates, these molecules are being explored across multiple organ systems, driven by their ability to modulate inflammation, mitochondrial efficiency, and metabolic signaling