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doi: 10.4049/jimmunol.1601896 113 BjornevikKCorteseMHealyBCKuhleJMinaMJLengYet al
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The resistance of hepatocellular carcinoma cells to chemotherapeutic agents such as sorafenib involves the abnormal expression of multiple transcription factors such as Nrf2, retinoblastoma (Rb) protein, hepatocyte nuclear factor 4(HNF4), HIC ZBTB Transcriptional Repressor 1 (HIC1), O-GlcNAcylated c-Jun, YAP/TAZ
Glutathiones reduced form (GSH): Carries an extra electron (hydrogen) Donates hydrogen (electron) to inflammation-causing free radicals to neutralize their effect Glutathione peroxidase enzyme Requires selenium Converts two hydrogen peroxides into two water molecules Glutathiones oxidized form (GSSG): State of glutathione after losing its electron Forms a disulfide bridge between two glutathione molecules Glutathione reductase enzyme Glutathione can be recycled back to its reduced form using NADPH (reducing agent, electron donor)
Rush AJ, Trivedi MH, Wisniewski SR, et al
