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Further, in a recent study involving perioperative NAC administration in patients undergoing major thoracic surgery, no patient receiving NAC required reoperation for bleeding (vs two subjects in the placebo cohort) [96]

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Furthermore, elevated NTBI levels stimulate monocyte chemoattractant protein (MCP-1) expression in ECs and vascular smooth muscle cells (VSMCs), thereby attracting monocytes/macrophages and accelerating foam cell formation and plaque evolution [181, 182]

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