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Rheumatoid arthritis patients receiving CoQ 10 (100 mg/day) for 2 months tended to have lower TFN- plasma levels than placebo-treated patients (Abdollahzad et al., 10 therapy in doses ranging from 60 to 300 mg/day caused no significant decrease in C-reactive protein while eliciting a significant reduction in IL-6 levels (Mazidi et al., 10 has been found to markedly attenuate the elevated expression of inflammatory and thrombotic risk markers in monocytes of patients with antiphospholipid syndrome, thereby improving endothelial function and mitochondrial activity in these patients (Perez-Sanchez et al., 2017)

Insect Biochem Mol Biol 34(12):12571268

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Taking these facts into consideration, the Food and Drug Administration (FDA) recommended that in order to establish the safety of a new antidiabetic therapy for T2DM, the manufacturers or sponsors should demonstrate that the new drug will not result in an unacceptable increase in cardiovascular risk and the trials population should also include high risk patients

Tb4 also has anti-inflammatory properties and decreases pro-inflammatory cytokines