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Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon

VEGF is up-regulated during hypoxia and orchestrate blood vessel formation mainly via activation of VEGF receptor-2 (VEGFR-2) expressed by endothelial cells [120]

Like it was unofficial or unproven, but as Voss explained, off-label doesnt mean unsafe, just that the treatment is being used in a way not originally specified in its FDA approval, and after seeing before-and-after photos, I decided to try it

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That means you might get a modest improvement, but you miss out on the synergistic effect of having several pathways activated at once

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