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Their hydrophobic moieties occupy the central cavity, while their positively charged polyamine tails extend into the selectivity filter (Figure 7E) ( 4.2 Agonist-bound non-conducting states The first full-length KAR structure in the agonist-bound non-conducting state was a cryo-EM structure of homomeric GluK2 bound to the high-affinity agonist SYM 2081 (Meyerson et al., 2014)