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This dysfunction affects not only the endothelial cells of the coronary vessels but more crucially those in the intramyocardial capillaries and endocardium, where they interact directly with adjacent cardiomyocytes [12]

Valiukas, Z., R

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This rapid elevation of FFAs paralleled to a peak in plasma insulin, likely due to a direct effect of G49 in the pancreas via GLP-1R as OXM does 42

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That is the information that lets a clinician separate an expected adjustment from something requiring action