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PMID: 40112692 Biochem Biophys Res CommunProteasome inhibition promotes mono-ubiquitination and nuclear translocation of mature (52 kDa) PINK1

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The proposed enzymatic reaction sequence is highlighted with green arrows, whereas the generally proposed pathway is shown with an orange arrow

Conclusion Taken together, ample evidence from animal and human studies in hypertension shows a clear association with increased vascular oxidative stress, attributable to the activation of several ROS sources including Nox, xanthine oxidase, mitochondrial respiratory chain and uncoupled eNOS