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The original fibroblast collagen-synthesis work reported stimulation beginning between 10 -12 and 10 -11 M and peaking at 10 -9 M that is, one nanomolar

The side-effect risk is just as high (or greater if uncontrolled)

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Epidemiological studies suggest the relative risks for these disorders is increased by approximately 25% following intrauterine exposure to acetaminophen, but the molecular mechanism remains unknown (Buhrer 2021)

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This GRAS designation does not imply FDA approval for therapeutic, drug, or compounded use , and it is sometimes misrepresented in marketing copy