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In some embodiments, the otic formulation or composition comprises between about 0.001% to about 30% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

1, 2 GLP-1 drugs build on this idea, but they act on multiple pathways at once, making them a potentially more powerful approach

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Although carnitines (12, 28, 29), L-ARG and NAC (13, 30, 31) have been demonstrated to modulate and reduce IR at high dosages (12, 30-32, 38), our present data support the positive synergistic role exerted by the combination of low dosages of ALC, L-carnitine, L-ARG and NAC on the improvement of PCOS metabolic parameters

Hernias (hiatal, traumatic, and congenital) In: Berk JE, editor