glutathione mitochondrial function Glutathione: Recent Insights and Role in Disease Frontiers | Glutathione and mitochondria

Dwibedi N, Findley AP, Wiener C, Shen C, Sambamoorthi U

High Homocysteine with MTHFR variants: The methylation cycle also controls the level of homocysteine , an important marker of heart disease risk

doi: 10.3389/fonc.2023.1099811

doi: 10.1016/0361-9230(87)90069-4

However, those with specific autoimmune conditions (particularly psoriasis or rosacea, where LL-37 is naturally overexpressed locally) should consult with their healthcare provider, as adding exogenous LL-37 could potentially exacerbate hyper-immune responses in those highly specific contexts

However, given the prevalence of the MTHFR variants in the general population and from which the laboratory reference values for Hcy are determined, any value near the upper limit of normal may be cause for concern