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The first peptide drug insulin was isolated in 1921 and became commercially available in 1923

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To further evaluate the effect of increased islet cholesterol content on GLP-1R function, islets isolated from wildtype (WT) mice were loaded with MCD saturated with cholesterol, which led to a significant increase in cholesterol content (Figure 1D)

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However, despite the widespread use of in vitro and in vivo modelssuch as transgenic animal models and brain organoidsto investigate the effects of natural compounds, these systems often fall short in capturing the full complexity of late-onset Alzheimers disease (LOAD)