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Low dose GLP-1 therapy attenuates pathological cardiac and hepatic remodelling in HFpEF independent of weight loss

As shown in Table 1 , inhibitors or antagonists of these targets have shown good results in animals, such as CXCR3, CXCR4, CXCL10, CXCL12, and CXCL13, especially the antibody of CXCL10 (MDX-1100) has entered clinical trials (25) ( Figure 2 )

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We believe the ability to blunt the weight regain that we typically see when patients stop GLP-1 agonist therapy like semaglutide is clinically significant, and reinforces the target product profile for nimacimab, which can potentially serve multiple needs in the obesity treatment paradigm, not just as a non-incretin add-on or combination, but also potentially in the maintenance setting. Punit Dhillon, President and CEO, added, While nimacimab 200 mg alone did not result in significant weight loss, we are encouraged that this same dose in combination with semaglutide demonstrated 26-week weight loss comparable to tirzepatide and other incretin combinations, without any added safety concerns

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