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That receptor spread is the reason people sometimes describe retatrutide as a "triple agonist" or, informally, a next-generation GLP-class compound

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Protein deserves special emphasis because adequate protein intake slows muscle loss during rapid weight reduction

Statistical analysis Using GraphPad Prism 9.3.0 (GraphPad Software, San Diego, CA, USA), one-way ANOVA followed by the Bonferroni multiple comparisons test was used to determine the level of statistical significance between experimental groups

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However, they can introduce additional risks, including hormonal disruption, cardiovascular strain, mood changes, acne, and fluid retention