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Additionally, a decreased response to oral methionine has been observed in men older than 45 years (Silberberg et al, 1997)

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Key considerations for protein targets: Use ideal body weight (IBW) or adjusted body weight for calculations, not current weight in patients with obesity Distribute protein across meals rather than concentrating in one sitting Monitor for signs of inadequate intake: fatigue, weakness, hair loss, or poor wound healing Reassess needs every 36 months as weight changes Consult with a registered dietitian for personalized recommendations GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists exert their appetite-suppressing effects through multiple mechanisms

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Elevated IL-6 and IL-8 have previously been associated with FM severity, indicating that multi-marker panels rather than single biomarkers might provide a more robust diagnostic approach