small molecule glp 1 agonist Orforglipron FDA Approval: Why the First Small-Molecule GLP-1 Pill Matters BioWorld

PLoS ONE 10(2):e0117106

Nature 2013

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All too often, that can mean muscle soreness and joint pain

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The subcutaneous route is used at much smaller doses than oral because a 100 mg injection would require two 50 mg vials and about 6 mL of liquid when each vial is mixed with 3.0 mL BAC water, which is too much for one subcutaneous site