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[2] Use of estradiol cypionate injection is contraindicated in individuals with undiagnosed abnormal vaginal bleeding, known or suspected breast cancer or other estrogen-dependent neoplasia, active or prior venous thromboembolism, recent arterial thrombo-occlusive disease such as stroke or myocardial infarction, severe hepatic impairment, a history of hypersensitivity to estradiol or any excipients, and in those who are or may become pregnant

In chronic diabetic state, total Tau depletion increasingly recognised as a potential biomarker associated with advanced neuronal loss and cytoskeletal collapse [25]

Weight reduction reduces progression to type 2 diabetes