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Triple agonists including retatrutide show exceptional promise based on remarkable weight loss and liver fat normalization in early trials, with dedicated MASH histology studies ongoing

They cited unverified risks and uncertainties regarding content and quality as the primary reasons to avoid them

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Android fat percentage, a surrogate for visceral adiposity, was reduced in all active intervention arms, with the largest reduction in the combination group compared with exercise alone or liraglutide alone

For many people, this happens because the body gets used to the medicines active ingredient, semaglutide, so over time, it may not work as well