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For those seeking non-invasive BDNF enhancement, the evidence supports high-intensity interval training (HIIT)12 weeks of HIIT produced 20% increases in hippocampal BDNF and improved cognitive flexibility in older adultsand flavonoid-rich diets containing polyphenols from sources like green tea and dark chocolate
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and CD68 (PG-M1) (clone KP1, monoclonal, antibody-online.com, dilution 1:200), and CD163 (clone ED2, Thermo Fisher Scientific, CA, USA, dilution 1:200), for M1 and M2 macrophages, respectively
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These effects are typically mild to moderate, dose-dependent, and tend to diminish with continued use and proper dose escalation