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This functional deficiency is most commonly seen in patients with liver or kidney disease
The 2023 GRAS designation permits marketing as a dietary supplement ingredient but NOT as a therapeutic agent
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These include: Inappropriate dosing or frequency Lack of proper diagnosis and monitoring Non-sterile injection technique increasing infection risk Absence of medical supervision for adverse reactions Financial cost without clinical benefit Patients should report any suspected adverse reactions to B12 injections via the MHRA Yellow Card scheme
These tissues are considered to be the last to decrease their thiamine content during TD and the first to replete it upon thiamine administration, with the liver serving as the thiamine depot for other tissues (156)
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