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Consequently, the SIRT1/Nrf2 signaling axis emerges as a critical pathway in maintaining chondrocyte integrity and attenuating the degenerative processes in the joint, offering a potential therapeutic strategy for managing osteoarthritis (Zhan et al., 2023

10.1056/NEJMoa1901118 35 JastreboffA

2- Diabetic Retinopathy (Eye Condition): Elevated glucose levels harm the tiny blood vessels in the retina and lead to oxidative stress and inflammation

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American Sleep Disorders Association and Sleep Research Society